Male pseudohermaphroditism in dogs: three case reports
نویسندگان
چکیده
Three Cocker Spaniel dogs, 2–3 months old, weighing 3–4 kg, were presented to the Chonbuk Animal Medical Centre, Chonbuk National University, with intersex anomalies. Physical, radiological, gross, histological, hormonal and cytogenetic studies were performed. Physical examination of the external genitalia revealed that the dogs possessed the vulva with an enlarged clitoris protruding from the vulvar juncture and the scrotum with an undescended testis in Case 1 and 2, and both testes remained undescended in Case 3. Hyperoestrogenaemia and low testosterone serum concentrations were found. Laparotomy revealed persistent Mullerian ducts (PMD) in Case 1 and 2, and abdominally located testicle(s) in all the cases. Histological examinations of the gonads revealed inactive seminiferous tubules. Cytogenetic analysis showed 78XY male karyotype in Case 1 and 2, whereas Case 3 showed 79XX female karyotype. The congenital defects were diagnosed as male pseudohermaphroditism (MPH) and PMD in Case 1 and 2, and XX sex reversal MPH in Case 3.
منابع مشابه
Coincidence of Persistent Müllerian duct syndrome and testicular tumors in dogs
BACKGROUND Persistent Müllerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism in dogs, is an abnormal sexual phenotype in males that is characterized by the existence of a hypoplastic oviduct, uterus, and cranial part of the vagina. Dogs suffering from PMDS are often accompanied by cryptorchidism. To date, it has been mainly found in the Miniature Schnauzer breed. CASE PRESE...
متن کامل5-Alpha-Reductase 2 Deficiency in a Woman with Primary Amenorrhea
Steroid 5-alpha-reductase 2 deficiency is a rare disorder leading to male pseudohermaphroditism, a condition characterized by incomplete differentiation of male genitalia in 46,XY patients. Here, we report a case of a 21-year-old woman from Ardabil who presented with primary amenorrhea, ambiguous genitalia, and lack of breast development. All of the serum hormone profiles were normal except for...
متن کاملMale Pseudohermaphroditism Presented with Sudden Cardiac Arrest
Torsades de pointes is a life-threatening arrhythmia associated with a number of causes, but is very rare among endocrinologic disorders. We report a case of male pseudohermaphroditism with hyperaldosteronism due to a 17α-hydroxylase deficiency presented with sudden cardiac arrest.
متن کاملIntra-Abdominal Testicular Seminoma in a Woman with Testicular Feminization Syndrome
We report a case of intra-abdominal testicular tumor in a 36-year-old married lady presenting with chief complaints of primary amenorrhea. The patient was later diagnosed with testicular feminization syndrome, a form of male pseudohermaphroditism. This testicular tumor was histologically proven as seminoma. Due to rarity, imaging findings in patients with testicular feminization syndrome and in...
متن کاملInternal Obturator Transposition Herniorraphy of Three Perineal Hernia Cases in Dogs
Case Description.: In this present study three cases of perineal hernia in dogs have beenpresented and new concepts in perineal herniorrhaphy have been introduced. A 5-year-oldintact male Spitz dog, a 6-year-old intact male dachshund dog and a 4.5-year-old sexuallyintact male Welsh corgi dog were referred with swelling around the anus and dyschesia.Clinical Findings: The owner complained about ...
متن کامل